Below is a selection of recent scientific publications in which a member of staff was involved.
Fenderico N, et al. Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells. Nature Communications, 2019; 10: 365. Displayed in the diagram are the binding-regions of two synthetic VHH inhibitors of LRP6 discovered in the project, L-P2-B10 (orange) and L-P2-D07 (red), and the overlap with the natural ligand DKK-C31 (magenta) on a LRP6 fragment (gray). The findings have increased our understanding of Wnt signalling with respect to cancer. The project was a collaboration under EU FP7 funding between University Medical Center Utrecht, Utrecht University, Isogenica Ltd., Attana AB and Medical University of Graz.
Hu Y, et al. Kinetic Control in Assembly of Plasmid DNA/Polycation Complex Nanoparticles. ACS Nano. 2019 Sep 24;13(9):10161-10178. The diagram shows the principles of turbulent mixing in the confined impinging jet device developed for large scale preparation of polymer nanoparticles carrying DNA for use in therapeutics. This was a result of work with Johns Hopkins University and Cancer Targeting Systems Inc.
Poole AJ, et al.. A C-terminal cysteine residue is required for peptide-based inhibition of the NGF/TrkA interaction at nM concentrations: implications for peptide-based analgesics. Scientific Reports 2019; Jan 30; 9(1):930. The diagram depicts the design of a peptide library prepared for maturation of an anti-NGF peptide for the treatment of pain. The design at each amino acid position (LH1-RH1) is compared to the prepared library, Exp and Obs, respectively. This was a collaboration between Aston University and Isogenica Ltd.
Biologics Consulting 